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Blog 7

Microdosing and Depression: Exploring the Positive Effects Backed by Science

Depression is a pervasive mental health condition that affects millions of people worldwide. Traditional treatments, such as therapy and medication, can be effective but may not work for everyone. In recent years, microdosing, the practice of taking sub-perceptual doses of psychedelic substances, has gained attention for its potential positive effects on individuals with depression. In this blog post, we delve into the scientific research supporting the use of microdosing as a complementary approach to alleviating symptoms of depression.


Understanding Microdosing:

Microdosing involves consuming minimal doses of psychedelic substances, such as psilocybin mushrooms, in quantities too small to induce a full-blown psychedelic experience. The goal is to experience subtle, positive effects while avoiding the hallucinogenic properties typically associated with larger doses.

1. Neural Plasticity and Neurogenesis:

Emerging research suggests that microdosing may promote neural plasticity and neurogenesis—the growth of new neurons—within the brain. These processes are crucial for rewiring neural pathways and improving mood and cognitive function. Psychedelics have been shown to enhance brain-derived neurotrophic factor (BDNF) levels, which are associated with the growth and protection of neurons.

2. Mood Enhancement and Emotional Well-being:

Studies have reported anecdotal evidence of microdosing leading to improved mood and emotional well-being in individuals with depression. Research conducted at Imperial College London found that microdosing with psilocybin resulted in enhanced emotional responsiveness and increased positive mood ratings.

3. Reduction in Symptoms of Depression:

Preliminary evidence suggests that microdosing may reduce symptoms of depression. A study published in the journal “Psychopharmacology” reported that individuals who microdosed with psilocybin experienced a significant reduction in depressive symptoms compared to the control group.

4. Enhanced Emotional Processing and Insight:

Psychedelics have been shown to facilitate emotional processing and enhance self-reflection. Microdosing may allow individuals with depression to gain new perspectives on their emotions, thoughts, and behavioral patterns. This increased insight can contribute to personal growth and potentially alleviate symptoms of depression.

5. Mindfulness and Acceptance:

Microdosing may promote mindfulness and acceptance, which are beneficial for individuals struggling with depression. Psychedelics can induce a state of increased present-moment awareness and acceptance of emotions, leading to improved emotional regulation and a reduction in depressive symptoms.

6. Impact on Default Mode Network:

The default mode network (DMN) is a brain network associated with self-referential thinking and rumination, which are often heightened in depression. Research suggests that psychedelics, including during microdosing, can modulate the DMN, potentially reducing depressive symptoms and promoting more adaptive patterns of thinking.


While research on microdosing and its effects on depression is still in its early stages, the available evidence suggests that microdosing may hold promise as a complementary approach for individuals with depression. The subtle doses of psychedelic substances used in microdosing have shown potential in enhancing mood, promoting emotional well-being, and reducing symptoms of depression.