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Blog 10

The Science Behind Microdosing Psilocybin: Exploring the Research and Findings

Microdosing psilocybin, the active compound in certain mushrooms, has gained attention in recent years as a potential tool for personal growth and well-being. While the practice of microdosing is relatively new, there is a growing body of research shedding light on its effects and benefits. In this blog post, we delve into the scientific research surrounding microdosing psilocybin and explore the findings that have contributed to its increasing popularity.

1. Understanding Microdosing:

Microdosing involves consuming sub-perceptual doses of psilocybin, typically around 1/10th to 1/20th of a regular dose. The aim is to experience the subtle effects of the compound without inducing a full psychedelic experience. This approach allows individuals to integrate microdosing into their daily lives while minimizing any potential disruptions.

2. Neuroplasticity and Neural Connectivity:

Research suggests that psilocybin has the potential to promote neuroplasticity, the brain’s ability to adapt and reorganize itself. Studies using functional magnetic resonance imaging (fMRI) have shown increased neural connectivity and synchronization in brain networks associated with cognition, emotion regulation, and creativity. These findings suggest that microdosing psilocybin may enhance neural plasticity, allowing for new connections and perspectives.

3. Mood Enhancement and Emotional Well-being:

Microdosing psilocybin has been reported to have positive effects on mood and emotional well-being. Studies have found that low doses of psilocybin can increase positive mood states, improve emotional regulation, and reduce symptoms of depression and anxiety. These effects are believed to be mediated by the compound’s influence on serotonin receptors in the brain.

4. Cognitive Enhancement and Creativity:

Several studies have explored the effects of microdosing on cognitive function and creativity. Research suggests that microdosing psilocybin may enhance cognitive flexibility, problem-solving abilities, and creative thinking. Individuals who microdose often report increased ideational fluency, originality, and openness to new experiences, which can contribute to enhanced creativity and innovation.

5. Neural Network Changes and Default Mode Network (DMN) Suppression:

The default mode network (DMN) is a brain network associated with self-referential thinking, mind-wandering, and rumination. Studies have shown that psilocybin, even in microdoses, can reduce the activity and connectivity of the DMN. This suppression is thought to allow for a more fluid and flexible mode of thinking, potentially facilitating introspection, self-reflection, and personal growth.

6. Mindfulness and Connectedness:

Microdosing psilocybin has been reported to increase mindfulness and a sense of connectedness. Users often describe feeling more present, aware, and connected to themselves, others, and the surrounding environment. These experiences align with the concept of “ego dissolution,” where one’s sense of self diminishes, leading to a greater sense of unity and interconnectedness.

7. Limitations and Future Research:

While the existing research on microdosing psilocybin is promising, it is important to acknowledge its limitations. Most studies to date have relied on self-report measures and anecdotal evidence, and there is a need for more controlled, double-blind studies to further understand the effects and mechanisms of microdosing. Additionally, individual variability in response to microdosing should be considered, as effects can vary based on factors such as dosage, frequency, and individual differences.


The scientific research on microdosing psilocybin provides fascinating insights into its potential benefits. From promoting neuroplasticity and mood enhancement to enhancing cognitive function and creativity, the findings suggest that microdosing may offer a unique experience and alternative for those looking for a alternative medicine.